COMPARTMENTS

PRR14 [ENSP00000441641]

Proline-rich protein 14; Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha . Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit . Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha . Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 .

Synonyms:  PRR14,  PRR14p,  hPRR14,  A0A024QZB5,  H3BND2 ...

Linkouts:  STRING  Pharos  UniProt