COMPARTMENTS

CAND1 [ENSP00000442318]

Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638,

Synonyms:  CAND1,  CAND1p,  hCAND1,  A0A0C4DGH5,  F5H6I6 ...

Linkouts:  STRING  Pharos  UniProt