COMPARTMENTS

MAP1LC3B2 [ENSP00000450524]

Microtubule-associated proteins 1A/1B light chain 3 beta 2; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family.

Synonyms:  MAP1LC3B2,  A6NCE7,  A6NCE7p,  hA6NCE7,  643246 ...

Linkouts:  STRING  Pharos  UniProt