USP6 localizations
USP6 [ENSP00000460380]
Ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Synonyms: USP6, USP6p, hUSP6, P35125, Q15635 ...
Linkouts: STRING Pharos UniProt
Fetching ...
Fetching ...
Fetching ...