COMPARTMENTS

LYPD8 [ENSP00000466070]

Ly6/PLAUR domain-containing protein 8; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.

Synonyms:  LYPD8,  LYPD8p,  hLYPD8,  Q6UX82,  Q6UX82p ...

Linkouts:  STRING  Pharos  UniProt