COMPARTMENTS

NR1H3 [ENSP00000477707]

Oxysterols receptor LXR-alpha; Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity . Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 . Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). ; Belongs to the nuclear hormone receptor family. NR1 subfamily.

Synonyms:  NR1H3,  NR1H3p,  hNR1H3,  B4DXU5,  B5MBY7 ...

Linkouts:  STRING  Pharos  UniProt