COMPARTMENTS

PAN2 [ENSP00000481859]

PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618,; Belongs to the peptidase C19 family. PAN2 subfamily.

Synonyms:  PAN2,  PAN2p,  hPAN2,  F8VXK8,  Q504Q3 ...

Linkouts:  STRING  Pharos  UniProt