COMPARTMENTS

SPAAR [ENSP00000490187]

Small regulatory polypeptide of amino acid response; [Isoform 2]: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids . Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V- ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 . Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity).

Synonyms:  SPAAR,  A0A1B0GVQ0,  158376,  ENSG00000235387,  ENSP00000489755 ...

Linkouts:  STRING  Pharos  UniProt