COMPARTMENTS

CBLC [ENSP00000494162]

E3 ubiquitin-protein ligase CBL-C; Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:18753381,

Synonyms:  CBLC,  A0A2R8Y647,  Q9ULV8,  Q9ULV8p,  hQ9ULV8 ...

Linkouts:  STRING  Pharos  UniProt