COMPARTMENTS

TRPM7 [ENSP00000495860]

Transient receptor potential cation channel subfamily M member 7; Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).

Synonyms:  TRPM7,  TRPM7p,  hTRPM7,  A0A024R5V1,  A0A0C4DGL2 ...

Linkouts:  STRING  Pharos  UniProt