COMPARTMENTS

SYNGAP1 [ENSP00000496007]

Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).

Synonyms:  SYNGAP1,  SYNGAP1p,  hSYNGAP1,  A0A0A0MQZ2,  A0A1B0GU28 ...

Linkouts:  STRING  Pharos  UniProt