COMPARTMENTS

H3Y1 [ENSP00000496014]

Histone H3.Y; Primate-specific variant histone H3, which constitutes a core component of nucleosomes . Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access . Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (Probable).

Synonyms:  H3Y1,  H3Y1p,  hH3Y1,  A0A2R8Y7G9,  H3.Y ...

Linkouts:  STRING  Pharos  UniProt