COMPARTMENTS

ESPN [ENSP00000496593]

Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.

Synonyms:  ESPN,  A0A0A0MSQ4,  A0A0J9YW00,  A0A0J9YWQ8,  A0A0J9YY76 ...

Linkouts:  STRING  Pharos  UniProt