MPIG6B localizations
MPIG6B [ENSP00000497720]
Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide . This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling . Appears to operate in a calcium-independent manner .
Synonyms: MPIG6B, MPIG6Bp, hMPIG6B, B0V023, B7ZLJ5 ...