COMPARTMENTS

PLAAT1 [ENSP00000498228]

Phospholipase A and acyltransferase 1; Exhibits both phospholipase A1/2 and acyltransferase activities . Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847). ECO:0000269|PubMed:22825852, ECO:0000269|PubMed:27623847,

Synonyms:  PLAAT1,  PLAAT1p,  hPLAAT1,  H7C3Y1,  Q9HDD0 ...

Linkouts:  STRING  Pharos  UniProt