GREM1 localizations
GREM1 [ENSP00000498748]
Gremlin-1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) . Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). ; Belongs to the DAN family.
Synonyms: GREM1, GREM1p, hGREM1, A6XAA7, H0YLY2 ...
Linkouts: STRING Pharos UniProt
Knowledge
| Name | Source | Evidence | Confidence |
|---|---|---|---|
| Cytosol | Reactome | TAS | ★★★★☆ |
| Nucleus | UniProtKB-SubCell | IEA | ★★★☆☆ |
| Plasma membrane | GO_Central | IBA | ★★★☆☆ |
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Predictions
| Name | Source | Evidence | Confidence |
|---|---|---|---|
| Cytosol | YLoc | 100.0% | ★★★☆☆ |
| Nucleus | PSORT | 26/32 | ★★★☆☆ |
| Cytosol | PSORT | 16.5/32 | ★★☆☆☆ |