COMPARTMENTS

ARHGEF18-2 [ENSP00000499655]

Rho guanine nucleotide exchange factor 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells . ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950,

Synonyms:  ARHGEF18,  114 kDa Rho-specific guanine nucleotide exchange factor,  23370,  A8MV62,  AC008878.3 ...

Linkouts:  STRING  Pharos  UniProt